ABSTRACT
Pulmonary rehabilitation has been demonstrated to improve symptoms and quality of
life of patients with chronic respiratory diseases. These benefits are not necessarily
associated with physiological improvement and have not been shown to improve mortality.
In this sense, its goals are palliative. Rehabilitation programs assess patients’
knowledge of their diseases, degree of symptoms such as dyspnea and fatigue, understanding
of common therapies, and capacity for exercise. The exercise component of pulmonary
rehabilitation improves function within the rehabilitation setting and may translate
to increased activity at home for some patients. The programs also offer additional
opportunities to identify for referring providers potentially undetected underlying
comorbidities such as sleep disturbances, anxiety, and depression, which contribute
to a poor quality of life for many patients. In addition, patients and their caregivers
can be encouraged to ask questions about interventions during exacerbations, the meaning
of advance care planning, and goals for end of life care with the intent that these
dialogues will lead to further discussions with their doctors and families.
KEYWORDS
End stage - palliative - advance directives - advance care planning
REFERENCES
1 World Health Organization .The Global Burden of Disease 2004 Update. Geneva; World
Health Organization 2008
2
Mannino D M, Buist A S.
Global burden of COPD: risk factors, prevalence, and future trends.
Lancet.
2007;
370(9589)
765-773
3
Chung F, Barnes N, Allen M et al..
Assessing the burden of respiratory disease in the UK.
Respir Med.
2002;
96
963-975
4
Methvin J N, Mannino D M, Casey B R.
COPD prevalence in southeastern Kentucky: the burden of lung disease study.
Chest.
2009;
135
102-107
5
Olson A L, Swigris J J, Lezotte D C, Norris J M, Wilson C G, Brown K K.
Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003.
Am J Respir Crit Care Med.
2007;
176
277-284
6 World Health Organization .Palliative Care. Copenhagen; WHO 2004
7 National Consensus Project for Quality Palliative Care .Clinical Practice Guidelines
for Quality Palliative Care. 2004. http://Available at: www.nationalconsensusproject.org
8
Lanken P N, Terry P B, Delisser H M ATS End-of-Life Care Task Force et al.
An official American Thoracic Society clinical policy statement: palliative care for
patients with respiratory diseases and critical illnesses.
Am J Respir Crit Care Med.
2008;
177
912-927
9
Morrison R S, Meier D E.
Clinical practice: palliative care.
N Engl J Med.
2004;
350
2582-2590
10
Mast K R, Salama M, Silverman G K, Arnold R M.
End-of-life content in treatment guidelines for life-limiting diseases.
J Palliat Med.
2004;
7
754-773
11
Curtis J R.
Palliative and end-of-life care for patients with severe COPD.
Eur Respir J.
2008;
32
796-803
12
Hofer M.
Advanced chronic lung disease: need for an active interdisciplinary approach.
Swiss Med Wkly.
2007;
137
593-601
13
Swigris J J, Kuschner W G, Jacobs S S, Wilson S R, Gould M K.
Health-related quality of life in patients with idiopathic pulmonary fibrosis: a systematic
review.
Thorax.
2005;
60
588-594
14
Wilt T J, Niewoehner D, MacDonald R, Kane R L.
Management of stable chronic obstructive pulmonary disease: a systematic review for
a clinical practice guideline.
Ann Intern Med.
2007;
147
639-653
15
American Thoracic Society .
Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement.
American Thoracic Society (ATS), and the European Respiratory Society (ERS).
Am J Respir Crit Care Med.
2000;
161(2 Pt 1)
646-664
16
Celli B R, MacNee W. ATS/ERS Task Force .
Standards for the diagnosis and treatment of patients with COPD: a summary of the
ATS/ERS position paper.
Eur Respir J.
2004;
23
932-946
17
O’Donnell D E, Aaron S, Bourbeau J et al..
Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary
disease - 2007 update.
Can Respir J.
2007;
14(Suppl B)
5B-32B
18
Kirschner K L.
When written advance directives are not enough.
Clin Geriatr Med.
2005;
21
193-209
19
Morrison R S, Meier D E.
High rates of advance care planning in New York City’s elderly population.
Arch Intern Med.
2004;
164
2421-2426
20
Teno J M, Weitzen S, Fennell M L, Mor V.
Dying trajectory in the last year of life: does cancer trajectory fit other diseases?.
J Palliat Med.
2001;
4
457-464
21 Glaser B, Strauss A. A Time for Dying. Piscataway, NJ; Aldine 2007
22
Lynn J.
Perspectives on care at the close of life: serving patients who may die soon and their
families: the role of hospice and other services.
JAMA.
2001;
285
925-932
23
Lunney J R, Lynn J, Hogan C.
Profiles of older Medicare decedents.
J Am Geriatr Soc.
2002;
50
1108-1112
24
Connors Jr A F, Dawson N V, Thomas C et al..
Outcomes following acute exacerbation of severe chronic obstructive lung disease.
The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes
and Risks of Treatments).
Am J Respir Crit Care Med.
1996;
154(4 Pt 1)
959-967
25
Lunney J R, Lynn J, Foley D J, Lipson S, Guralnik J M.
Patterns of functional decline at the end of life.
JAMA.
2003;
289
2387-2392
26
Qaseem A, Snow V, Shekelle P Clinical Efficacy Assessment Subcommittee of the American
College of Physicians et al.
Evidence-based interventions to improve the palliative care of pain, dyspnea, and
depression at the end of life: a clinical practice guideline from the American College
of Physicians.
Ann Intern Med.
2008;
148
141-146
27
Selecky P A, Eliasson C A, Hall R I, Schneider R F, Varkey B, McCaffree D R. American
College of Chest Physicians .
Palliative and end-of-life care for patients with cardiopulmonary diseases: American
College of Chest Physicians position statement.
Chest.
2005;
128
3599-3610
28
Solano J P, Gomes B, Higginson I J.
A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic
obstructive pulmonary disease and renal disease.
J Pain Symptom Manage.
2006;
31
58-69
29
Nishimura K, Izumi T, Tsukino M, Oga T.
Dyspnea is a better predictor of 5-year survival than airway obstruction in patients
with COPD.
Chest.
2002;
121
1434-1440
30
Gysels M, Higginson I J.
Access to services for patients with chronic obstructive pulmonary disease: the invisibility
of breathlessness.
J Pain Symptom Manage.
2008;
36
451-460
31
Reardon J Z, Lareau S C, ZuWallack R.
Functional status and quality of life in chronic obstructive pulmonary disease.
Am J Med.
2006;
119(10, Suppl 1)
32-37
32
Michaels C, Meek P M.
The language of breathing among individuals with chronic obstructive pulmonary disease.
Heart Lung.
2004;
33
390-400
33
Seamark D A, Seamark C J, Halpin D M.
Palliative care in chronic obstructive pulmonary disease: a review for clinicians.
J R Soc Med.
2007;
100
225-233
34
Seamark D A, Blake S D, Seamark C J, Halpin D M.
Living with severe chronic obstructive pulmonary disease (COPD): perceptions of patients
and their carers: an interpretative phenomenological analysis.
Palliat Med.
2004;
18
619-625
35
Lynn J, Ely E W, Zhong Z et al..
Living and dying with chronic obstructive pulmonary disease.
J Am Geriatr Soc.
2000;
48(5, Suppl)
S91-S100
36
Velloso M, Jardim J R.
Study of energy expenditure during activities of daily living using and not using
body position recommended by energy conservation techniques in patients with COPD.
Chest.
2006;
130
126-132
37
Walke L M, Gallo W T, Tinetti M E, Fried T R.
The burden of symptoms among community-dwelling older persons with advanced chronic
disease.
Arch Intern Med.
2004;
164
2321-2324
38
Brinkley T E, Leng X, Miller M E et al..
Chronic inflammation is associated with low physical function in older adults across
multiple comorbidities.
J Gerontol A Biol Sci Med Sci.
2009;
64
455-461
39
Lareau S C, Meek P M, Press D, Anholm J D, Roos P J.
Dyspnea in patients with chronic obstructive pulmonary disease: does dyspnea worsen
longitudinally in the presence of declining lung function?.
Heart Lung.
1999;
28
65-73
40
Janssen D J, Spruit M A, Wouters E F, Schols J M.
Daily symptom burden in end-stage chronic organ failure: a systematic review.
Palliat Med.
2008;
22
938-948
41
Elkington H, White P, Addington-Hall J, Higgs R, Edmonds P.
The healthcare needs of chronic obstructive pulmonary disease patients in the last
year of life.
Palliat Med.
2005;
19
485-491
42
Breslin E, van der Schans C, Breukink S et al..
Perception of fatigue and quality of life in patients with COPD.
Chest.
1998;
114
958-964
43
Krachman S, Minai O A, Scharf S M.
Sleep abnormalities and treatment in emphysema.
Proc Am Thorac Soc.
2008;
5
536-542
44
Cormick W, Olson L G, Hensley M J, Saunders N A.
Nocturnal hypoxaemia and quality of sleep in patients with chronic obstructive lung
disease.
Thorax.
1986;
41
846-854
45
Chaouat A, Weitzenblum E, Krieger J, Ifoundza T, Oswald M, Kessler R.
Association of chronic obstructive pulmonary disease and sleep apnea syndrome.
Am J Respir Crit Care Med.
1995;
151
82-86
46
Hiestand D, Phillips B.
The overlap syndrome: chronic obstructive pulmonary disease and obstructive sleep
apnea.
Crit Care Clin.
2008;
24
551-563, vii
,
47
Weitzenblum E, Chaouat A, Kessler R, Canuet M.
Overlap syndrome: obstructive sleep apnea in patients with chronic obstructive pulmonary
disease.
Proc Am Thorac Soc.
2008;
5
237-241
48
Sanders M H, Newman A B, Haggerty C L Sleep Heart Health Study et al.
Sleep and sleep-disordered breathing in adults with predominantly mild obstructive
airway disease.
Am J Respir Crit Care Med.
2003;
167
7-14
49
Maurer J, Rebbapragada V, Borson S ACCP Workshop Panel on Anxiety and Depression in
COPD et al.
Anxiety and depression in COPD: current understanding, unanswered questions, and research
needs.
Chest.
2008;
134(4, Suppl)
43S-56S
50
Hill K, Geist R, Goldstein R S, Lacasse Y.
Anxiety and depression in end-stage COPD.
Eur Respir J.
2008;
31
667-677
51
Kunik M E, Roundy K, Veazey C et al..
Surprisingly high prevalence of anxiety and depression in chronic breathing disorders.
Chest.
2005;
127
1205-1211
52
Kim H F, Kunik M E, Molinari V A et al..
Functional impairment in COPD patients: the impact of anxiety and depression.
Psychosomatics.
2000;
41
465-471
53
Ferguson C J, Stanley M, Souchek J, Kunik M E.
The utility of somatic symptoms as indicators of depression and anxiety in military
veterans with chronic obstructive pulmonary disease.
Depress Anxiety.
2006;
23
42-49
54
Hynninen K M, Breitve M H, Wiborg A B, Pallesen S, Nordhus I H.
Psychological characteristics of patients with chronic obstructive pulmonary disease:
a review.
J Psychosom Res.
2005;
59
429-443
55
Sareen J, Jacobi F, Cox B J, Belik S L, Clara I, Stein M B.
Disability and poor quality of life associated with comorbid anxiety disorders and
physical conditions.
Arch Intern Med.
2006;
166
2109-2116
56
Borak J, Sliwiński P, Piasecki Z, Zieliński J.
Psychological status of COPD patients on long term oxygen therapy.
Eur Respir J.
1991;
4
59-62
57
Jones P W, Baveystock C M, Littlejohns P.
Relationships between general health measured with the sickness impact profile and
respiratory symptoms, physiological measures, and mood in patients with chronic airflow
limitation.
Am Rev Respir Dis.
1989;
140
1538-1543
58
Kvaal K, Macijauskiene J, Engedal K, Laake K.
High prevalence of anxiety symptoms in hospitalized geriatric patients.
Int J Geriatr Psychiatry.
2001;
16
690-693
59
Bailey P H.
The dyspnea–anxiety–dyspnea cycle: COPD patients’ stories of breathlessness: “It’s
scary/when you can’t breathe.”
Qual Health Res.
2004;
14
760-778
60
Gudmundsson G, Gislason T, Janson C et al..
Risk factors for rehospitalisation in COPD: role of health status, anxiety and depression.
Eur Respir J.
2005;
26
414-419
61
Howard C, Hallas C N, Wray J, Carby M.
The relationship between illness perceptions and panic in chronic obstructive pulmonary
disease.
Behav Res Ther.
2009;
47
71-76
62
Katon W, Lin E H, Kroenke K.
The association of depression and anxiety with medical symptom burden in patients
with chronic medical illness.
Gen Hosp Psychiatry.
2007;
29
147-155
63
Chetta A, Gerra G, Foresi A et al..
Personality profiles and breathlessness perception in outpatients with different gradings
of asthma.
Am J Respir Crit Care Med.
1998;
157
116-122
64
Roy-Byrne P P, Davidson K W, Kessler R C et al..
Anxiety disorders and comorbid medical illness.
Gen Hosp Psychiatry.
2008;
30
208-225
65
van Ede L, Yzermans C J, Brouwer H J.
Prevalence of depression in patients with chronic obstructive pulmonary disease: a
systematic review.
Thorax.
1999;
54
688-692
66
van Manen J G, Bindels P J, Dekker F W, IJzermans C J, van der Zee J S, Schadé E.
Risk of depression in patients with chronic obstructive pulmonary disease and its
determinants.
Thorax.
2002;
57
412-416
67
Hankin C S, Spiro III A, Miller D R, Kazis L.
Mental disorders and mental health treatment among U.S. Department of Veterans Affairs
outpatients: the Veterans Health Study.
Am J Psychiatry.
1999;
156
1924-1930
68
Quint J K, Baghai-Ravary R, Donaldson G C, Wedzicha J A.
Relationship between depression and exacerbations in COPD.
Eur Respir J.
2008;
32
53-60
69
Xu W, Collet J P, Shapiro S et al..
Independent effect of depression and anxiety on chronic obstructive pulmonary disease
exacerbations and hospitalizations.
Am J Respir Crit Care Med.
2008;
178
913-920
70
Engström C P, Persson L O, Larsson S, Sullivan M.
Health-related quality of life in COPD: why both disease-specific and generic measures
should be used.
Eur Respir J.
2001;
18
69-76
71
O'Neill E S.
Illness representations and coping of women with chronic obstructive pulmonary disease:
a pilot study.
Heart Lung.
2002;
31
295-302
72
Elofsson L C, Ohlén J.
Meanings of being old and living with chronic obstructive pulmonary disease.
Palliat Med.
2004;
18
611-618
73
Hirayama F, Lee A H, Binns C W, Leong C C, Hiramatsu T.
Physical activity of patients with chronic obstructive pulmonary disease: implications
for pulmonary rehabilitation.
J Cardiopulm Rehabil Prev.
2008;
28
330-334
74
Pitta F, Troosters T, Spruit M A, Probst V S, Decramer M, Gosselink R.
Characteristics of physical activities in daily life in chronic obstructive pulmonary
disease.
Am J Respir Crit Care Med.
2005;
171
972-977
75
Watz H, Waschki B, Meyer T, Magnussen H.
Physical activity in patients with COPD.
Eur Respir J.
2009;
33
262-272
76
Kaptein A A, Scharloo M, Fischer M J et al..
Illness perceptions and COPD: an emerging field for COPD patient management.
J Asthma.
2008;
45
625-629
77
Bourbeau J, Julien M, Maltais F Chronic Obstructive Pulmonary Disease axis of the
Respiratory Network Fonds de la Recherche en Santé du Québec et al.
Reduction of hospital utilization in patients with chronic obstructive pulmonary disease:
a disease-specific self-management intervention.
Arch Intern Med.
2003;
163
585-591
78
Seemungal T A, Donaldson G C, Paul E A, Bestall J C, Jeffries D J, Wedzicha J A.
Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary
disease.
Am J Respir Crit Care Med.
1998;
157(5 Pt 1)
1418-1422
79
Ferrer M, Alonso J, Morera J The Quality of Life of Chronic Obstructive Pulmonary
Disease Study Group et al.
Chronic obstructive pulmonary disease stage and health-related quality of life.
Ann Intern Med.
1997;
127
1072-1079
80
van Manen J G, Bindels P J, Dekker F W et al..
The influence of COPD on health-related quality of life independent of the influence
of comorbidity.
J Clin Epidemiol.
2003;
56
1177-1184
81
Cully J A, Graham D P, Stanley M A et al..
Quality of life in patients with chronic obstructive pulmonary disease and comorbid
anxiety or depression.
Psychosomatics.
2006;
47
312-319
82
Ek K, Ternestedt B M.
Living with chronic obstructive pulmonary disease at the end of life: a phenomenological
study.
J Adv Nurs.
2008;
62
470-478
83
Simpson A C, Rocker G M.
Advanced chronic obstructive pulmonary disease: impact on informal caregivers.
J Palliat Care.
2008;
24
49-54
84
Kasuya R T, Polgar-Bailey P, Takeuchi R.
Caregiver burden and burnout: a guide for primary care physicians.
Postgrad Med.
2000;
108
119-123
85
Gore J M, Brophy C J, Greenstone M A.
How well do we care for patients with end stage chronic obstructive pulmonary disease
(COPD)? A comparison of palliative care and quality of life in COPD and lung cancer.
Thorax.
2000;
55
1000-1006
86
Goodridge D, Lawson J, Duggleby W, Marciniuk D, Rennie D, Stang M.
Health care utilization of patients with chronic obstructive pulmonary disease and
lung cancer in the last 12 months of life.
Respir Med.
2008;
102
885-891
87
Au D H, Udris E M, Fihn S D, McDonell M B, Curtis J R.
Differences in health care utilization at the end of life among patients with chronic
obstructive pulmonary disease and patients with lung cancer.
Arch Intern Med.
2006;
166
326-331
88
Claessens M T, Lynn J, Zhong Z Study to Understand Prognoses and Preferences for Outcomes
and Risks of Treatments et al.
Dying with lung cancer or chronic obstructive pulmonary disease: insights from SUPPORT.
J Am Geriatr Soc.
2000;
48(5, Suppl)
S146-S153
89
Christakis N A, Lamont E B.
Extent and determinants of error in physicians’ prognoses in terminally ill patients:
prospective cohort study.
West J Med.
2000;
172
310-313
90
Muntwyler J, Abetel G, Gruner C, Follath F.
One-year mortality among unselected outpatients with heart failure.
Eur Heart J.
2002;
23
1861-1866
91
Allen L A, Yager J E, Funk M J et al..
Discordance between patient-predicted and model-predicted life expectancy among ambulatory
patients with heart failure.
JAMA.
2008;
299
2533-2542
92
Fox E, Landrum-McNiff K, Zhong Z, Dawson N V, Wu A W, Lynn J. SUPPORT Investigators.
Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments
.
Evaluation of prognostic criteria for determining hospice eligibility in patients
with advanced lung, heart, or liver disease.
JAMA.
1999;
282
1638-1645
93
Coventry P A, Grande G E, Richards D A, Todd C J.
Prediction of appropriate timing of palliative care for older adults with non-malignant
life-threatening disease: a systematic review.
Age Ageing.
2005;
34
218-227
94
Davison S N.
Facilitating advance care planning for patients with end-stage renal disease: the
patient perspective.
Clin J Am Soc Nephrol.
2006;
1
1023-1028
95
Larson D G, Tobin D R.
End-of-life conversations: evolving practice and theory.
JAMA.
2000;
284
1573-1578
96
Curtis J R, Wenrich M D, Carline J D, Shannon S E, Ambrozy D M, Ramsey P G.
Patients’ perspectives on physician skill in end-of-life care: differences between
patients with COPD, cancer, and AIDS.
Chest.
2002;
122
356-362
97
Morrison R S, Meier D E.
High rates of advance care planning in New York City’s elderly population.
Arch Intern Med.
2004;
164
2421-2426
98
Elkington H, White P, Addington-Hall J, Higgs R, Pettinari C.
The last year of life of COPD: a qualitative study of symptoms and services.
Respir Med.
2004;
98
439-445
99
Carrese J A, Mullaney J L, Faden R R, Finucane T E.
Planning for death but not serious future illness: qualitative study of housebound
elderly patients.
BMJ.
2002;
325
125
100
Habraken J M, Pols J, Bindels P J, Willems D L.
The silence of patients with end-stage COPD: a qualitative study.
Br J Gen Pract.
2008;
58
844-849
101
Silveira M J, DiPiero A, Gerrity M S, Feudtner C.
Patients’ knowledge of options at the end of life: ignorance in the face of death.
JAMA.
2000;
284
2483-2488
102
Gillick M R.
Decision making near life’s end: a prescription for change.
J Palliat Med.
2009;
12
121-125
103
Morrison R S, Morrison E W, Glickman D F.
Physician reluctance to discuss advance directives: an empiric investigation of potential
barriers.
Arch Intern Med.
1994;
154
2311-2318
104
Elkington H, White P, Higgs R, Pettinari C J.
GPs’ views of discussions of prognosis in severe COPD.
Fam Pract.
2001;
18
440-444
105
Rocker G M, Dodek P M, Heyland D K. Canadian Researchers at the End of Life Network
.
Toward optimal end-of-life care for patients with advanced chronic obstructive pulmonary
disease: insights from a multicentre study.
Can Respir J.
2008;
15
249-254
106
McNeely P D, Hébert P C, Dales R E et al..
Deciding about mechanical ventilation in end-stage chronic obstructive pulmonary disease:
how respirologists perceive their role.
CMAJ.
1997;
156
177-183
107
Sullivan K E, Hébert P C, Logan J, O’Connor A M, McNeely P D.
What do physicians tell patients with end-stage COPD about intubation and mechanical
ventilation?.
Chest.
1996;
109
258-264
108
Hardin K A, Meyers F, Louie S.
Integrating palliative care in severe chronic obstructive lung disease.
COPD.
2008;
5
207-220
109
Nici L, Donner C, Wouters E ATS/ERS Pulmonary Rehabilitation Writing Committee et
al.
American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation.
Am J Respir Crit Care Med.
2006;
173
1390-1413
110
American Thoracic Society .
Pulmonary rehabilitation—1999.
Am J Respir Crit Care Med.
1999;
159(5 Pt 1)
1666-1682
111
Troosters T, Casaburi R, Gosselink R, Decramer M.
Pulmonary rehabilitation in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med.
2005;
172
19-38
112
Ries A L, Bauldoff G S, Carlin B W et al..
Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines.
Chest.
2007;
131(5, Suppl)
4S-42S
113
Maltais F, Bourbeau J, Shapiro S Chronic Obstructive Pulmonary Disease Axis of Respiratory
Health Network, Fonds de recherche en santé du Québec et al.
Effects of home-based pulmonary rehabilitation in patients with chronic obstructive
pulmonary disease: a randomized trial.
Ann Intern Med.
2008;
149
869-878
114
Bowen J B, Thrall R S, ZuWallack R L, Votto J J.
Long-term benefits of short-stay inpatient pulmonary rehabilitation in severe chronic
obstructive pulmonary disease.
Monaldi Arch Chest Dis.
1999;
54
189-192
115
Wijkstra P J, van der Mark T W, Kraan J, van Altena R, Koëter G H, Postma D S.
Effects of home rehabilitation on physical performance in patients with chronic obstructive
pulmonary disease (COPD).
Eur Respir J.
1996;
9
104-110
116 Global Initiative on Obstructive Lung Disease .http://Available at: www.goldcopd.org
117
Zuwallack R.
The nonpharmacologic treatment of chronic obstructive pulmonary disease: advances
in our understanding of pulmonary rehabilitation.
Proc Am Thorac Soc.
2007;
4
549-553
118
Ries A L.
Pulmonary rehabilitation: summary of an evidence-based guideline.
Respir Care.
2008;
53
1203-1207
119
Eaton T, Garrett J E, Young P et al..
Ambulatory oxygen improves quality of life of COPD patients: a randomised controlled
study.
Eur Respir J.
2002;
20
306-312
120
Nonoyama M L, Brooks D, Lacasse Y, Guyatt G H, Goldstein R S.
Oxygen therapy during exercise training in chronic obstructive pulmonary disease.
Cochrane Database Syst Rev.
2007;
(2)
CD005372
121
Nonoyama M L, Brooks D, Guyatt G H, Goldstein R S.
Effect of oxygen on health quality of life in patients with chronic obstructive pulmonary
disease with transient exertional hypoxemia.
Am J Respir Crit Care Med.
2007;
176
343-349
122
Uronis H E, Abernethy A P.
Oxygen for relief of dyspnea: what is the evidence?.
Curr Opin Support Palliat Care.
2008;
2
89-94
123
Sandland C J, Morgan M D, Singh S J.
Patterns of domestic activity and ambulatory oxygen usage in COPD.
Chest.
2008;
134
753-760
124
Booth S, Wade R, Johnson M, Kite S, Swannick M, Anderson H. Expert Working Group of
the Scientific Committee of the Association of Palliative Medicine .
The use of oxygen in the palliation of breathlessness: a report of the expert working
group of the Scientific Committee of the Association of Palliative Medicine.
Respir Med.
2004;
98
66-77
125
Schwartzstein R M, Lahive K, Pope A, Weinberger S E, Weiss J W.
Cold facial stimulation reduces breathlessness induced in normal subjects.
Am Rev Respir Dis.
1987;
136
58-61
126
Standish L J, Kozak L, Congdon S.
Acupuncture is underutilized in hospice and palliative medicine.
Am J Hosp Palliat Care.
2008;
25
298-308
127
Bausewein C, Booth S, Gysels M, Higginson I.
Non-pharmacological interventions for breathlessness in advanced stages of malignant
and non-malignant diseases.
Cochrane Database Syst Rev.
2008;
(2)
CD005623
128
Hill K, Goldstein R, Gartner E J, Brooks D.
Daily utility and satisfaction with rollators among persons with chronic obstructive
pulmonary disease.
Arch Phys Med Rehabil.
2008;
89
1108-1113
129
Gupta R B, Brooks D, Lacasse Y, Goldstein R S.
Effect of rollator use on health-related quality of life in individuals with COPD.
Chest.
2006;
130
1089-1095
130
Gupta R, Goldstein R, Brooks D.
The acute effects of a rollator in individuals with COPD.
J Cardiopulm Rehabil.
2006;
26
107-111
131
Probst V S, Troosters T, Coosemans I et al..
Mechanisms of improvement in exercise capacity using a rollator in patients with COPD.
Chest.
2004;
126
1102-1107
132
Solway S, Brooks D, Lau L, Goldstein R.
The short-term effect of a rollator on functional exercise capacity among individuals
with severe COPD.
Chest.
2002;
122
56-65
133
Honeyman P, Barr P, Stubbing D G.
Effect of a walking aid on disability, oxygenation, and breathlessness in patients
with chronic airflow limitation.
J Cardiopulm Rehabil.
1996;
16
63-67
134
Wesmiller S W, Hoffman L A.
Evaluation of an assistive device for ambulation in oxygen dependent patients with
COPD.
J Cardiopulmonary Rehabil.
1994;
14
122-126
135
Roomi J, Yohannes A M, Connolly M J.
The effect of walking aids on exercise capacity and oxygenation in elderly patients
with chronic obstructive pulmonary disease.
Age Ageing.
1998;
27
703-706
136
Neder J A, Sword D, Ward S A, Mackay E, Cochrane L M, Clark C J.
Home based neuromuscular electrical stimulation as a new rehabilitative strategy for
severely disabled patients with chronic obstructive pulmonary disease (COPD).
Thorax.
2002;
57
333-337
137
Bourjeily-Habr G, Rochester C L, Palermo F, Snyder P, Mohsenin V.
Randomised controlled trial of transcutaneous electrical muscle stimulation of the
lower extremities in patients with chronic obstructive pulmonary disease.
Thorax.
2002;
57
1045-1049
138
Vivodtzev I, Pépin J L, Vottero G et al..
Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical
stimulation in severely deconditioned and malnourished COPD.
Chest.
2006;
129
1540-1548
139
Vivodtzev I, Lacasse Y, Maltais F.
Neuromuscular electrical stimulation of the lower limbs in patients with chronic obstructive
pulmonary disease.
J Cardiopulm Rehabil Prev.
2008;
28
79-91
140
Zanotti E, Felicetti G, Maini M, Fracchia C.
Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical
ventilation: effect of electrical stimulation.
Chest.
2003;
124
292-296
141
Suzuki M, Namura K, Ohno Y et al..
The effect of acupuncture in the treatment of chronic obstructive pulmonary disease.
J Altern Complement Med.
2008;
14
1097-1105
142
Keenan S P, Mehta S.
Noninvasive ventilation for patients presenting with acute respiratory failure: the
randomized controlled trials.
Respir Care.
2009;
54
116-126
143
Clini E, Sturani C, Rossi A Rehabilitation and Chronic Care Study Group, Italian Association
of Hospital Pulmonologists (AIPO) et al.
The Italian multicentre study on noninvasive ventilation in chronic obstructive pulmonary
disease patients.
Eur Respir J.
2002;
20
529-538
144
Keilty S E, Ponte J, Fleming T A, Moxham J.
Effect of inspiratory pressure support on exercise tolerance and breathlessness in
patients with severe stable chronic obstructive pulmonary disease.
Thorax.
1994;
49
990-994
145
Hawkins P, Johnson L C, Nikoletou D et al..
Proportional assist ventilation as an aid to exercise training in severe chronic obstructive
pulmonary disease.
Thorax.
2002;
57
853-859
146
Bianchi L, Foglio K, Porta R, Baiardi R, Vitacca M, Ambrosino N.
Lack of additional effect of adjunct of assisted ventilation to pulmonary rehabilitation
in mild COPD patients.
Respir Med.
2002;
96
359-367
147
Dreher M, Storre J H, Windisch W.
Noninvasive ventilation during walking in patients with severe COPD: a randomised
cross-over trial.
Eur Respir J.
2007;
29
930-936
148
Clini E M, Ambrosino N.
Nonpharmacological treatment and relief of symptoms in COPD.
Eur Respir J.
2008;
32
218-228
149
Kolodziej M A, Jensen L, Rowe B, Sin D.
Systematic review of noninvasive positive pressure ventilation in severe stable COPD.
Eur Respir J.
2007;
30
293-306
150
Duiverman M L, Wempe J B, Bladder G, Kerstjens H A, Wijkstra P J.
Health-related quality of life in COPD patients with chronic respiratory failure.
Eur Respir J.
2008;
32
379-386
151
Curtis J R, Engelberg R A.
Measuring success of interventions to improve the quality of end-of-life care in the
intensive care unit.
Crit Care Med.
2006;
34(11, Suppl)
S341-S347
152
Schettino G, Altobelli N, Kacmarek R M.
Noninvasive positive-pressure ventilation in acute respiratory failure outside clinical
trials: experience at the Massachusetts General Hospital.
Crit Care Med.
2008;
36
441-447
153
Olofson J, Dellborg C, Sullivan M, Midgren B, Caro O, Bergman B.
Qualify of life and palliation predict survival in patients with chronic alveolar
hypoventilation and nocturnal ventilatory support.
Qual Life Res.
2009;
18
273-280
154
Jennings A L, Davies A N, Higgins J P, Gibbs J S, Broadley K E.
A systematic review of the use of opioids in the management of dyspnoea.
Thorax.
2002;
57
939-944
155
Uronis H E, Currow D C, Abernethy A P.
Palliative management of refractory dyspnea in COPD.
Int J Chron Obstruct Pulmon Dis.
2006;
1
289-304
156
Abernethy A P, Currow D C, Frith P, Fazekas B S, McHugh A, Bui C.
Randomised, double blind, placebo controlled crossover trial of sustained release
morphine for the management of refractory dyspnoea.
BMJ.
2003;
327
523-528
157
Rocker G M, Sinuff T, Horton R, Hernandez P.
Advanced chronic obstructive pulmonary disease: innovative approaches to palliation.
J Palliat Med.
2007;
10
783-797
158
Lacasse Y, Martin S, Lasserson T J, Goldstein R S.
Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease.
A Cochrane systematic review.
Eura Medicophys.
2007;
43
475-485
159
de Godoy D V, de Godoy R F.
A randomized controlled trial of the effect of psychotherapy on anxiety and depression
in chronic obstructive pulmonary disease.
Arch Phys Med Rehabil.
2003;
84
1154-1157
160
Emery C F, Schein R L, Hauck E R, MacIntyre N R.
Psychological and cognitive outcomes of a randomized trial of exercise among patients
with chronic obstructive pulmonary disease.
Health Psychol.
1998;
17
232-240
161
Kunik M E, Veazey C, Cully J A et al..
COPD education and cognitive behavioral therapy group treatment for clinically significant
symptoms of depression and anxiety in COPD patients: a randomized controlled trial.
Psychol Med.
2008;
38
385-396
162
Rose C, Wallace L, Dickson R et al..
The most effective psychologically-based treatments to reduce anxiety and panic in
patients with chronic obstructive pulmonary disease (COPD): a systematic review.
Patient Educ Couns.
2002;
47
311-318
163
Coventry P A, Gellatly J L.
Improving outcomes for COPD patients with mild-to-moderate anxiety and depression:
a systematic review of cognitive behavioural therapy.
Br J Health Psychol.
2008;
13(Pt 3)
381-400
164
Eiser N, Harte R, Spiros K, Phillips C, Isaac M T.
Effect of treating depression on quality-of-life and exercise tolerance in severe
COPD.
COPD.
2005;
2
233-241
165
Sachs S, Weinberg R L.
Pulmonary rehabilitation for dyspnea in the palliative-care setting.
Curr Opin Support Palliat Care.
2009;
3
112-119
166
Heffner J E, Fahy B, Barbieri C.
Advance directive education during pulmonary rehabilitation.
Chest.
1996;
109
373-379
167
Heffner J E, Fahy B, Hilling L, Barbieri C.
Attitudes regarding advance directives among patients in pulmonary rehabilitation.
Am J Respir Crit Care Med.
1996;
154(6 Pt 1)
1735-1740
168
Heffner J E.
Role of pulmonary rehabilitation in palliative care.
Respir Care.
2000;
45
1365-1371
discussion 1371-1375
169
Gerald L B, Sanderson B, Fish L et al..
Advance directives in cardiac and pulmonary rehabilitation patients.
J Cardiopulm Rehabil.
2000;
20
340-345
170
Heffner J E, Barbieri C.
End-of-life care preferences of patients enrolled in cardiovascular rehabilitation
programs.
Chest.
2000;
117
1474-1481
171
Heffner J E, Fahy B, Hilling L, Barbieri C.
Outcomes of advance directive education of pulmonary rehabilitation patients.
Am J Respir Crit Care Med.
1997;
155
1055-1059
172
Perkins H S.
Controlling death: the false promise of advance directives.
Ann Intern Med.
2007;
147
51-57
173
Collins L G, Parks S M, Winter L.
The state of advance care planning: one decade after SUPPORT.
Am J Hosp Palliat Care.
2006;
23
378-384
174
Schickedanz A D, Schillinger D, Landefeld C S, Knight S J, Williams B A, Sudore R L.
A clinical framework for improving the advance care planning process: start with patients’
self-identified barriers.
J Am Geriatr Soc.
2009;
57
31-39
James R McCormickM.D.
Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky
740 South Limestone, L543 Kentucky Clinic, Lexington, KY 40536-0284
Email: jmccorm@email.uky.edu